Electrophysiologic substrate of torsade de pointes: Dispersion of repolarization or early afterdepolarizations?
نویسندگان
چکیده
منابع مشابه
Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT Conditions.
BACKGROUND The arrhythmogenic effects of hyperthermia have been highlighted in the Brugada syndrome but remain largely unexplored in other arrhythmic syndromes. The present study examines the effect of hyperthermia on transmural dispersion of action potential duration (TD-APD), early afterdepolarization (EAD) activity, and torsade de pointes (TdP) under long-QT conditions. METHODS AND RESULTS...
متن کاملSotalol-induced torsade de pointes.
A case of sotalol-induced polymorphous ventricular tachycardia (torsade de pointes) is presented. The patient had moderately prolonged Q-T interval before medication with sotalol with further prolongation after application of this drug. Electrophysiological study during rechallenge with sotalol demonstrated a uniform ventricular tachycardia with a somewhat polymorphous onset; whether or not thi...
متن کاملDrug-induced torsade de pointes.
A73-year-old man with mild coronary artery disease and a dilated cardiomyopathy presented to the emergency room with a hemodynamically stable wide-QRS tachycardia. His 12-lead ECG revealed episodes of ventriculoatrial block, and a diagnosis of ventricular tachycardia (VT) was made (Figure 1). Intravenous procainamide restored sinus rhythm. Tachycardia recurred, and a second bolus of intravenous...
متن کاملCisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation.
BACKGROUND Cisapride, a gastrointestinal prokinetic agent, was recently withdrawn from the market because of its propensity to induce torsade de pointes (TdP) arrhythmias. The present study examines the electrophysiological actions of cisapride in the isolated arterially perfused canine left ventricular wedge preparation. METHODS AND RESULTS Transmembrane action potentials from epicardial and...
متن کاملCisapride-Induced Transmural Dispersion of Repolarization and Torsade de Pointes in the Canine Left Ventricular Wedge Preparation During Epicardial Stimulation
Background—Cisapride, a gastrointestinal prokinetic agent, was recently withdrawn from the market because of its propensity to induce torsade de pointes (TdP) arrhythmias. The present study examines the electrophysiological actions of cisapride in the isolated arterially perfused canine left ventricular wedge preparation. Methods and Results—Transmembrane action potentials from epicardial and M...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1989
ISSN: 0735-1097
DOI: 10.1016/0735-1097(89)90069-7